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Treatment of Dermatomyositis and Immune-Mediated Necrotizing Myopathy with Poor Muscle Recovery with Steroids and IVIg: Intractable Dermatomyositis and Immune-Mediated Necrotizing Myopathy Kazuma Sugie 1 1Department of Neurology, Nara Medical University School of Medicine Keyword: 皮膚筋炎 , 免疫介在性壊死性筋症 , 筋病理 , リツキシマブ , 血漿交換療法 , dermatomyositis , immune-mediated necrotizing myopathy , muscle biopsy , rituximab , plasma exchange pp.537-544
Published Date 2022/5/1
DOI https://doi.org/10.11477/mf.1416202077
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Abstract

Among idiopathic inflammatory myopathies, dermatomyositis and immune-mediated necrotizing myopathy are distinguished by their different clinicopathological features. Corticosteroids are administered as the first-line treatment for both, and immunosuppressive agents and intravenous immunoglobulin important second-line treatments. Since some patients show resistance to these therapies, it is necessary to considering additional treatment based on muscle pathology, muscle imaging, and systemic complications such as malignancy and interstitial lung disease, in addition to the careful evaluation of muscle strength. However, more effective therapeutic strategies are not yet well-established for refractory cases because the available therapeutic agents are limited. Therefore, the development of novel therapies is required in the future.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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