雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Clinical Features of Myasthenia Gravis as an Immune-related Adverse Event Shigeaki Suzuki 1 1Department of Neurology, Keio University School of Medicine Keyword: 免疫関連有害事象 , 免疫チェックポイント阻害薬 , 重症筋無力症 , 心筋炎 , Kv1.4抗体 , immune-related adverse event , immune checkpoint inhibitor , myasthenia gravis , myocarditis , anti-Kv1.4 antibodies pp.27-32
Published Date 2024/1/1
DOI https://doi.org/10.11477/mf.1416202554
  • Abstract
  • Look Inside
  • Reference

Abstract

Neurological and muscular immune-related adverse events (irAEs) associated with cancer treatment using immune checkpoint inhibitors (ICIs) may show a diverse clinical presentation. Myasthenia gravis (MG) represents a serious irAE associated with the aforementioned therapy. Recent studies have discussed the clinical features of MG that occurs as an irAE (irAE-MG). The incidence of irAE-MG is estimated to be 1%. This complication occurs during the early phase of ICI treatment and rapidly worsens, resulting in severe bulbar muscle involvement and myasthenic crisis and significantly elevated serum creatine kinase levels. MG and myositis, which may occur concomitantly as irAEs are often indistinguishable. Myocarditis is occasionally observed in patients with irAE-MG and can cause severe heart failure and lethal arrhythmias, with a fatal outcome. Kv1.4 antibodies serve as biomarkers of severe irAE-MG and myocarditis. Immunotherapy with corticosteroids is effective for management of irAE-MG and should be initiated promptly. Collaboration between consulting neurologists is necessary for safe management of cancer immunotherapy.


Copyright © 2024, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

関連文献

もっと見る

文献を共有