雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Parkinson's Disease as a Network Disorder Atsushi Nambu 1,2 , Satomi Chiken 1,2 1Division of System Neurophysiology, National Institute for Physiological Sciences 2Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Keyword: 大脳基底核 , 運動異常症 , パーキンソン病 , 病態生理 , 定位脳手術 , basal ganglia , movement disorder , Parkinson's disease , pathophysiology , stereotactic surgery pp.1159-1171
Published Date 2020/11/1
DOI https://doi.org/10.11477/mf.1416201669
  • Abstract
  • Look Inside
  • Reference

Abstract

Network disorders of the basal ganglia may underlie the pathophysiology of movement disorders, such as Parkinson's disease and dystonia. The following models have been proposed to explain network disorders: (1) the firing rate model: an activity imbalance between the direct, indirect, and hyperdirect pathways induces changes in the mean firing rate of the output nuclei of the basal ganglia and causes hypokinetic or hyperkinetic movement disorders, (2) the firing pattern model: oscillatory and/or synchronized activity in the basal ganglia disturbs information processing in this area, resulting in motor symptoms and, (3) the dynamic activity model: abnormal neuronal modulations through the direct, indirect, and hyperdirect pathways disrupt the balance between movement-related inhibition and surrounding excitation in the output nuclei, which leads to motor symptoms. We present a critical analysis of these models in this review. Stereotactic surgery, which involves the application of high-frequency electrical stimulation (deep brain stimulation) or coagulation of a small area in the basal ganglia is an effective therapeutic strategy to treat movement disorders. We have also discussed the mechanism underlying the beneficial effects of stereotactic surgery.


Copyright © 2020, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

関連文献

もっと見る

文献を共有