Neurological Manifestations of COVID-19: Meningoencephalitis and Encephalopathy Hideto Nakajima 1 1Division of Neurology, Department of Medicine, Nihon University School of Medicine Keyword: 新型コロナウイルス感染症 , 脳炎 , 急性壊死性脳症 , 急性散在性脳脊髄炎 , coronavirus , COVID-19 , SARS-CoV-2 , encephalitis , acute necrotizing encephalopathy , acute disseminated encephalomyelitis pp.1031-1037
Published Date 2020/10/1
DOI https://doi.org/10.11477/mf.1416201644
  • Abstract
  • Look Inside
  • Reference


Although COVID-19 is predominantly characterized by respiratory symptoms, various types of diseases such as cerebral infarction, thrombosis, encephalitis/encephalopathy, and autoimmune disorders have been reported to be associated with COVID-19. Possible mechanisms for neurological complications of COVID-19 are 1) direct invasion of the virus into the nervous system, 2) neurological symptoms of COVID-19 as a systemic disease, 3) parainfectious neurological complications, and 4) an accidental neurological disorder during a pandemic are assumed. In this paper, encephalitis and encephalopathy have been reviewed as neuronal complications of COVID-19, discussing these pathological conditions and whether SARS-CoV-2 targets the central nervous system.

Copyright © 2020, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院