New Treatment for Patients with Neurosarcoidosis Maki Asami 1 , Kazuto Matsunaga 1 1Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University Keyword: 神経サルコイドーシス , 治療 , プレドニゾロン , メトトレキサート , 抗TNF-α製剤 , neurosarcoidosis , treatment , prednisolone , methotrexate , anti-TNF inhibitor pp.883-890
Published Date 2020/8/1
DOI https://doi.org/10.11477/mf.1416201613
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Diagnosis of possible neurosarcoidosis (NS) involves assessment of clinical presentation suggestive of NS and exclusion of other diagnoses, whereas its definitive diagnosis is challenging and it requires positive nervous system histology. Due to an exceptionally low incidence, limited data are available on the optimal therapeutic options for NS. NS is commonly associated with other sarcoidosis forms; however, the patients with NS experience more frequent relapses than with other organs sarcoidosis. While corticosteroid therapy is considered as the first-line of treatment for NS, secondary treatment options with immunosuppressive agents such as methotrexate, azathioprine, mycophenolate mofetil and tumor necrosis factor (TNF)-α inhibitors are considered based on the severity of NS manifestations and the disease status.

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