BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 11 (November 2018)

Tourette Syndrome Yu Hamamoto 1 , Yukiko Kano 2,3 1Department of Child and Adolescent Psychiatry, Tokyo Metropolitan Children's Medical Center 2Department of Child Psychiatry, The University of Tokyo Hospital 3Department of Child Neuropsychiatry, Graduate School of Medicine, University of Tokyo Keyword: トゥレット症候群 , 皮質-線条体-視床-皮質回路 , 脳深部刺激療法 , ヘテロジニアス , Tourette syndrome , cortico-striato-thalamo-cortical circuits , deep brain stimulation , heterogeneous pp.1237-1245
Published Date 2018/11/1
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Tourette syndrome (TS) is a neurodevelopmental disorder. TS was formerly considered to be a psychogenic disease; however, TS has recently been thought to be a heterogeneous disease with neurological bases and involving environmental and genetic factors. For example, it has been suggested that neurotransmitters including dopamine and cortico-striato-thalamo-cortical circuits are suggested to be associated with TS pathogenesis. According to these recent evidence, in addition to pharmacotherapy as the standard treatment, deep brain stimulation is being applied for patients with treatment-refractory TS in clinical settings.

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BRAIN and NERVE-神経研究の進歩
70巻11号 (2018年11月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院