BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 3 (March 2018)

Cortical Midline Structures: “Self” and “Pain” Shigeyuki Kan 1,2 , Satoru Miyauchi 2 1Department of Pain Medicine, Osaka University Graduate School of Medicine 2Center for Information and Neural Networks, National Institute of Information and Communications Technology Keyword: 安静時ネットワーク , デフォルトモードネットワーク , サリエンスネットワーク , 自己認知 , 痛み , resting-state network , RSN , default mode network , DMN , salience network , SN , self-cognition , pain pp.247-252
Published Date 2018/3/1
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Emerging evidence indicates that cortical midline structures (CMS) (which consist of the orbitomedial prefrontal cortex (OMPFC), dorsomedial prefrontal cortex (DMPFC), anterior cingulate cortex (ACC), and precuneus/posterior cingulate cortex (pC/PCC)) have a critical role in generating a model of the self. These regions also serve as hub regions for the default mode network (DMN) or salience network (SN). Furthermore, regions of the CMS overlap with pain-related regions such as the so-called “pain matrix,” suggesting that pain has unique attributes compared to other sensations like vision. Previous studies have reported that disturbances of the CMS relate to chronic pain, as well as neurological and psychiatric diseases. The considerable overlap between regions involved in pain and those involved in self-cognition may provide important insights not only into the pathology of chronic pain and cognitive aspects of pain, but also for understanding self-representation in the brain.

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BRAIN and NERVE-神経研究の進歩
70巻3号 (2018年3月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院