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Role of Reelin during Layer Formation in the Cerebral Neocortex Kazunori Nakajima 1 1Department of Anatomy, Keio University School of Medicine Keyword: リーリン , 層形成 , ターミナルトランスロケーション , 原皮質帯 , 神経細胞凝集 , Reelin , layer formation , terminal translocation , primitive cortical zone , neuronal aggregation pp.931-937
Published Date 2016/8/1
DOI https://doi.org/10.11477/mf.1416200532
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Abstract

Reelin controls the neuronal layer formation in the developing cerebral neocortex. The Reelin glycoprotein is mainly secreted from Cajal-Retzius cells in the marginal zone, and it guides the proper aggregation of the migrating neurons in a birth-dependent “inside-out” manner. Reelin also regulates the final process of neuronal migration (terminal translocation and somal translocation) by activating integrin and N-cadherin. It is also expressed around the subventricular zone and it controls the behavior of the migrating neurons.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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