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Neuronal Distribution in the Cerebral Cortex and Its Significance in Schizophrenia Ken-ichiro Kubo 1 , Kazunori Nakajima 1 1Department of Anatomy, Keio University School of Medicine Keyword: development , neuron , schizophrenia , migration , cortex pp.1133-1145
Published Date 2013/10/1
DOI https://doi.org/10.11477/mf.1416101612
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Abstract

 Abnormal cortical architectures have been identified as one of the microscopic neuropathological findings of schizophrenia. Among such findings, the altered distribution of neurons is suggestive of deficits during brain development and is consistent with the neurodevelopmental hypothesis of schizophrenia. However, the relationship between altered neuronal distribution and emergence of psychosis is unclear. In this review, we discuss the neurodevelopmental hypothesis of schizophrenia and describe the normal architecture of the neocortex and the recent findings regarding neocortical development. Thereafter, we summarize the abnormal cortical architectures reported for the brains of patients with schizophrenia. Furthermore, on the basis of the recent findings regarding cortical development, we suggest a mechanism for the formation of abnormal cortical architectures in schizophrenia and speculate how it could relate to some of the symptoms of schizophrenia.


Copyright © 2013, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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