BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 67, Issue 11 (November 2015)
Japanese

Pathology of the Peripheral Nervous System in Guillain-Barré Syndrome Yuta Nakano 1 , Takashi Kanda 1 1Department of Neurology and Clinical Neuroscience, Yamaguchi University, Graduate School of Medicine Keyword: ギラン・バレー症候群 , 脱髄型 , 軸索型 , 末梢神経 , 神経病理 , Guillain-Barré syndrome , AIDP , AMAN , MSAN , pathology pp.1329-1339
Published Date 2015/11/1
DOI https://doi.org/10.11477/mf.1416200303
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Abstract

Guillain-Barré syndrome is composed of two distinct clinicopathological entities: acute inflammatory demyelinating polyradiculoneuropathy (AIDP), and acute motor or motor and sensory axonal neuropathy (AMAN and AMSAN). AIDP is characterized by the patchily distributed demyelinative foci throughout the peripheral nervous system (PNS), whereas in AMAN/AMSAN primary axonal degeneration is observed in the PNS, particularly accentuated at the spinal nerve roots. The aim of this article is to provide an overview of previous findings regarding GBS pathology and thus, to elucidate the pathomechanisms of this life-threatening disorder. The most critical cause for AIDP may be the autoimmune attack on the Schwann cell membrane wrapping the myelinated nerve fibers, and that in AMAN/AMSAN may be an antibody-mediated attack on the axolemma at the nodes of Ranvier.


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基本情報

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BRAIN and NERVE-神経研究の進歩
67巻11号 (2015年11月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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