Developmental Disorders and Dementia Akira Midorikawa 1,2,3 1Department of Psychology, Faculty of Letters, Chuo University 2Department of Neurology, Showa University School of Medicine 3Neuroscience Research Australia Keyword: 自閉症スペクトラム , 注意欠陥/多動性障害 , 学習障害 , 脆弱性 , 認知症 , autistic spectrum disorder (ASD) , attention-deficit/hyperactivity disorder (ADHD) , learning disorder (LD) , vulnerability , dementia pp.1125-1132
Published Date 2015/9/1
DOI https://doi.org/10.11477/mf.1416200271
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This article reviews the relationship between developmental disorders and dementia with ageing. Persons with autistic spectrum disorder (ASD) are vulnerable to life events, even in their old age. In certain cases, senile persons with undiagnosed ASD, who developed maladaptive behaviors after negative life events, were considered as having a behavioral variant of frontotemporal dementia (bvFTD). However, to our knowledge, there are no reports on the relationships between ASD and bvFTD. Alternatively, there are only a limited number of reports, which address the relationships between developmental disorders and dementia. One such relationship is that in patients with dementia with Lewy bodies (DLB) and those with Parkinson's disease (PD), who also show a tendency for having attention-deficit/hyperactivity disorder (ADHD) at a younger age. Another such relationship is seen in patients with primary progressive aphasia (PPA) who show a high occurrence of learning disability (LD) among their first-degree relatives. These results imply that the neurotransmitter pathway or language network in the brain is vulnerable in some subjects. These retrospective studies have demonstrated a possible relationship between developmental disorders and dementia; however, no study has shown a causality of developmental disorders and dementia.

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