BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 66, Issue 5 (May 2014)

The Adverse Effects of Anticholinergic Drugs Hirotaka Iwaki 1 , Masahiro Nomoto 1 1Department of Neurology and Clinical Pharmacology, Ehime University Graduate School of Medicine Keyword: アセチルコリン , 抗コリン薬 , 抗コリン活性 , 認知機能低下 , せん妄 , acetylcholine , anticholinergic drug , anticholinergic activity , cognitive decline , delusion pp.551-560
Published Date 2014/5/1
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Acetylcholine is one of the main neurotransmitters. It is involved in autonomic activities of the peripheral organs and forms a part of complicated neural networks in the central nervous system. Anticholinergic drugs are used in the treatment of various diseases, and many drugs have anticholinergic side effects. Thus, estimating the total burden of anticholinergic activity of drugs is important to assess the related adverse effects for patients taking such drugs. Serum anticholinergic activity (SAA) is measured using a competitive radioreceptor binding assay of muscarinic receptors. In addition to this direct measurement, several drug scales like the Anticholinergic Drug Scale (ADS), Anticholinergic Cognitive Burden Scale (ACB), and Anticholinergic Risk Scale (ARS) have been developed to estimate the total anticholinergic burden of drugs. These measurements have been used to demonstrate that certain drugs may be responsible for the cognitive impairment in the elderly or certain groups of patients with neurologic disorders. Clinicians should be aware of the impact of such drugs because central adverse effects are often obscure in these patient groups and are easily overlooked.

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BRAIN and NERVE-神経研究の進歩
66巻5号 (2014年5月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院