The Relationship between Autonomic Nerve Function and Atrial Fibrillation Induced by Intracoronary Administration of Acetylcholine Teruo Shiraki 1 , Masahiro Murakami 1 , Masayuki Doi 1 , Akio Kajiyama 1 , Muneaki Kuriyama 1 , Megumi Kawashima 1 , Tokuzo Arao 1 , Yoshitaka Takuma 1 , Takuro Masaka 1 , Tetsuji Seito 1 , Seitomi Tanaka 1 , Daiji Saito 1 1Department of Internal Medicine, Iwakuni National Hospital Keyword: 自律神経機能 , 心房細動 , アセチルコリン , autonomic nerve function , acetylcholine , atrial fibrillation pp.635-638
Published Date 1999/6/15
DOI https://doi.org/10.11477/mf.1404901919
  • Abstract
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 The relationship between autonomic nerve function and atrial fibrillation which is induced by acetylcholine is unknown. For the diagnosis of vasospastic angina, we performed acetylcholine provocation tests in 30 patients without significant coronary stenosis. 6 patients experienced atrial fibrillation 〔17%, Af (+) group〕, 30 patients did not 〔83%, Af (-) group〕. We performed ultrasonography and 24 Holter ECG. We compared markers of left cardiac function (LAD, A/R, A/E, LVEF, LVEDP) and autonomic nerve function utilizing heart rate variability (AVRR, SDRR, CVRR, RR 50, LF, HF, LF/HF). However, there was no significant difference in the markers in the two groups. These findings suggest that the effect of autonomic nerve function on atrial fibrillation induced by acetylcholine is small and other factors such as electrophysiological disorder of the atria may play an important role.

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