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Deposition and Clearance of β-Amyloid in the Brain Koichi Wakabayashi 1 , Yasuo Miki 1 1Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine Keyword: Alzheimer's disease , amyloid β-protein , glial cell , perivascular clearance , tau pp.1433-1444
Published Date 2013/12/1
DOI https://doi.org/10.11477/mf.1416101664
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Abstract

 Amyloid β-protein (Aβ) is deposited as senile plaques and vascular amyloid in the brain of patients with Alzheimer's disease as well as in a significant proportion of non-demented elderly individuals. Microglia play critical roles in the uptake and proteolytic clearance of both the soluble and fibrillary forms of Aβ. Astrocytes separate fibrillary Aβ from neurons by extending hypertrophic processes and internalizing the Aβ into endosomes/lysosomes, suggesting their role in the degradation of Aβ. Recent studies have shown that perivascular clearance of Aβ is a two-step process, involving (i) the uptake of Aβ by glia limitans astrocytes and (ii) perivascular or transendothelial clearance after their secretion into the perivascular space.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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