雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Mild Cognitive Impairment in Parkinson's Disease Kenji Wada 1 , Kenji Nakashima 1 1Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University Keyword: Parkinson's disease with dementia , prevalence , biomarker , neuroimaging , diagnostic criteria pp.1365-1375
Published Date 2012/12/1
DOI https://doi.org/10.11477/mf.1416101362
  • Abstract
  • Look Inside
  • Reference

Abstract

 Parkinson's disease (PD), a neurodegenerative disease, has been traditionally defined by its characteristic motor symptoms. Non-motor symptoms, including mood disorder, psychosis, sleep disturbance, autonomic dysfunction, and cognitive impairment, have being recently recognized as symptoms of PD. Cognitive impairment or dementia is one of the critical symptoms during the advanced stages of PD and is associated with increased disability and reduced quality of life of both patients and caregivers. The point prevalence of dementia in PD is about 30%, and its incidence rate in PD patients is 4-6 times higher than that in age-matched controls. The term mild cognitive impairment (MCI) has been adopted to describe the potential prodromal stage of dementia in PD, which has been gaining increasing attention. Several studies have reported the clinical features, epidemiology, biomarkers, and neuropathology of MCI in PD; however, neither the precise definitions nor the employed criteria were consistent across these studies. Recently, the Movement Disorder Society Task Force proposed new diagnostic criteria for MCI in PD to allow clinicians to identify PD patients with increased risk of dementia. Further studies are needed to validate the proposed criteria in daily clinical practice.


Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

関連文献

もっと見る

文献を共有