雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

The Transcription Factor Network that Regulates Neural Development Ryoichiro Kageyama 1 1Institute for Virus Research, Kyoto University Keyword: basic region-helix-loop-helix (bHLH) factor , homeodomain , Notch signaling , neural stem cell pp.329-333
Published Date 2008/4/1
DOI https://doi.org/10.11477/mf.1416100253
  • Abstract
  • Look Inside
  • Reference

Abstract

 In the developing nervous system, neural stem cells initially proliferate extensively by symmetric cell division and then give rise to neurons by asymmetric cell division. After production of neurons, neural stem cells finally differentiate into glial cells. These processes are regulated by basic helix-loop-helix (bHLH) transcription factors: the repressor-type bHLH factors promote maintenance of neural stem cells and differentiation of glial cells, whereas the activator-type bHLH factors induce production of neurons. There are many subtypes of neurons, and bHLH factors alone are not sufficient but other factors such as homeodomain factors are required for specification of these neuronal subtypes. These transcription factors will be useful for regeneration of the nervous system.


Copyright © 2008, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

関連文献

もっと見る

文献を共有