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過去6年間に当院泌尿器科および救急部に初診入院加療を行った急性腎盂腎炎98例を対象にその治療内容を検討した。複雑性腎盂腎炎患者83例中,57例(69%)が第2世代セフェム・ペニシリン系薬にて反応治癒し,尿培養にて46%より大腸菌が検出され,初発時には単純性腎盂腎炎同様に各種抗菌薬に高い感受性を示すと考えられた。また結石性腎盂腎炎患者23例中,15例(65%)は抗菌化学療法のみにて治癒したが,5例(21%)が平均1.8日にて敗血性ショックに陥っており,特にCRP≧15mg/dlの症例では早期に尿路管理を施行すべきであると考えられた。
We treated 98 patients with acute pyelonephritis in a period of 6 years between 1998 and 2003. 13 patients out of 15 with acute uncomplicated pyelonephritis responded well to penicillins or 2nd-generation cephalosporins. Of the 83 patients with complicated pyelonephritis,57(69%)responded well to 2nd generation cephalosporins. There was a significant difference in serum CRP level between the patients who responded to penicillin or 2nd generation cephalosporins and those who needed hospitalization with administration of 3rd/4th generation cephalosporins(p<0.05). We experienced 23 acute pyelonephritis patients with urolithiasis,and 5 developed septic shock. WBC and CRP levels were significantly higher in septic shock patients(p<0.05),who subsequently required treatments to release the obstruction.(Rinsho Hinyokika 58:423-426,2004)
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