二次内分泌療法開始後にDICを伴う重篤な病勢進行をきたした再燃性前立腺癌

Severe disease progression with DIC during secondary endocrine therapy in recurrent prostate cancer

77歳，男性。臨床病期D2の前立腺癌にて除睾術が施行されている。今回，再燃をきたし二次内分泌療法としてCAB療法を施行。治療開始13日後より，DICおよび神経症状を併発した骨痛の増強を認めた。臨床経過より，二次内分泌療法が，急激な病勢進行に関与している可能性も考えられた。

A 77-year-old man with recurrent prostate cancer after castration was treated with combined androgen blockade as the secondary endocrine therapy. Thirteen days after the therapy,disseminated intravascular coagulation syndrome with bone pain and neurological symptoms were developed. This condition became improved gradually by systematic DIC therapy. It was considered that secondary endocrine therapy was related to cause severe disease progression.