PAPILLOMATOSIS CARCINOIDES（ORAL FLORID PAPILLOMATOSIS）

　口腔内に白い表面をもつ丘疹または腫瘍を形成して，ロイコプラキーや有棘細胞癌と間違えやすい疾患が，oral florid papillomatosis^1）またはpapillomatosis mucosae carcinoides^2）の病名で，1960年以来，耳鼻科，皮膚科領域で10例前後，発表されているが，わが国皮膚科領域では，未だ報告に接しない．

　われわれは，口角にくり返し「有棘細胞癌」を生じ，しかも10年近くにわたつて転移をおこさない症例に遭遇し，臨床，組織両所見からoral florid papillomatosisと考えるにいたつた．また，以前に有棘細胞癌として診断され，加療されていた症例で，本症と考えられるものがあつたので，これらを合せて報告する．

　Two cases of papillomatosis carcinoides (oral florid papillomatosis) in 68-and 60-year-old men were reported.

　Both cases showed verrucous proliferation on the oral mucosa and adjacent skin and were treated as spinous cell carcinoma. Both cases had had the lesion for more than ten years and experienced recurrences after resection. However, no metastasis had been noticed. X-ray treatment was effective, but one case underwent resection after irradiation.

　This disease is caused by the proliferation of spinous cells. However, the disease is differentiated from spinous cell carcinoma by slow growth, rare occurrence of metastasis and histologic benignity, that is, intact basal layer and no atypicality of the cells.

　There are about ten reported cases in the world. 'Verrucous carcinoma', reported mostly in the oral surgery and 'leucoplakia verrucosa' are considered to be nearly identical with this disease.