Colloid milium—特に膠状物質の起源およびその本態について

COLLOID MILIUM:ESPECIALLY ON NATURE AND ORIGIN OF COLLOID SUBSTANCE

　膠様稗粒腫Colloid miliumは年とともにその報告が増すにつれてそれほど稀なものではないことが知られてきたが，最近では本症の主要変化である膠様物質の本態，起源について興味がもたれ，諸家により多くの新事実が報告されて本症の病因の解明に新たな手がかりを与えている．しかしいずれもまだ推測の域を出ておらず，真因はなお不明といわざるを得ない．一方本症の発症については個人的素因ならびに周囲の環境が何らかの役割を果していることは諸家の認めるところであり，さらに地域的にも好発地帯があるかのごとくである。最近われわれは比較的典型と思われる本症を経験し，その本態について若干の考察を試みたのでここに報告する。

typical case of this disease on the cheeks, eyelids, and nasal root in a 47-year-old female Drmer with a 5 years' history.

Laboratory tests revealed mild disturbances in the hepatocellular function. Serum cholesterol level was 190 mg/dl, and there was no abnormality in serum protein fractions. Histologic specimen revealed various-sized, amorphous, homogeneous masses in the upper and middermis. They were faintly eosinophilic by H & E. strongly positive by PAS (diastase resistant), negative by congo red, negative by alcian blue, and weakly mctachromatic by crystal violet.

Differences between the colloid and amyloid substance on electron microscopic findings, and es-pecially their nature and origin were discussed. They both might be produced by fibroblasts in the dermis. The colloid substance seemed to have rather akin character to the ground substance of the dermis than amyloid.