頭蓋骨にいわゆるpunched-out lesionが認められたLetterer-Siwe病剖検例

AN AUTOPSY CASE OF LETTERER-SIWE DISEASE WITH SPECIAL REFERENCE TO BONE LESIONS

　今回われわれは，頭蓋骨に円形の骨欠損，いわゆるpunched-out lesionが認められたLetterer-Siwe病症例を経験し，剖検により該骨病変を組織学的に検索することができた。

　以下この症例の概略を報告し，併せて本症における骨変化に関し考察したい。

A typical case in a 7-month-old girl was reported. The punched-out lesion in the skull was revealed by autopsy, as a cyst without palpable resistance of bone in its base. Histiocytic proliferations in the bone marrow, and secondary osteolysis were proved by histologic studies.

Since foci of the proliferation of histiocytes without ostcolysis were found in the bones of the extremi-ties where punched-out lesion could not be proved, the existence of histiocytic proliferation even in the bone with normal roentogenogram would be quite possible.