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XANTHOMATA WITH SECONDARY HYPERCHOLESTEREMIA DUE TO LIVER DISEASE Gyo FUKUSHI 1 , Akira YAMANOUCHI 1 , Shinichi KAMIHARA 1 1Department of Dermatology, Aomori Prefectural Hospital pp.1093-1098
Published Date 1968/10/1
DOI https://doi.org/10.11477/mf.1412200413
  • Abstract
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A 36-year-old woman had an episode of fever and jaundice with cholecystitis and liver function disturbance 4 months before the first visit, which was improved by 3 months' treatment

At that time she found yellow lesions on the eyelids and palms.

At her first, she had jaundice, and flat yellow nodules on both the canthi, and cord-like yellow nodules on the neck, axillae, cubital regions, palms, groins, and flexor surfaces of fingers.

Laboratory studies of patient's blood disclosed the following values : icteric index 15.3, total cholesterol 524 mg/dl, total lipid 813 mg/dl, alkaline phosphatase 49.6 u, GOT 113 u, GPT 142 u, A/G 1.70. Serum protein fractions by Tiseliuse were as follows : Albumin 62.9%, α1-globulin 3.9%, α2-globulin 12.0%, β-globulin 10.3%, and γ-globulin 10.9%.

Histologic specimen from yellow nodule revealed dense infiltration of foam cells containing neutral fat and cholesterol in the papillary and subpapillary layer of the dermis.

Histologic section of liver biopsy showed swollen and turbid liver cells, mild fibrosis and inflammatory infiltrate in and around the Glison's capsule.

After 5 months treatment of Clofibrate and Thioctic acid xanthomata except those on the eyelids disappeared, and results of laboratory examinations returned to normal level.


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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