CHRONIC DISCOID AND SYSTEMIC LUPUS ERYTHEMATOSUS IN SISTERS Toshihiro MIZUMOTO 1 , Iwao TAKASHIMA 1 , Khoki KAKU 1 1Department of Dermatology, University of Hokkaido Faculty of Medicine pp.883-890
Published Date 1968/8/1
DOI https://doi.org/10.11477/mf.1412200388
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Case 1 : A 38-year-old woman mentioned erythema on the right cheek and nasal back at the age of 28. She had been treated with antimalarials for about one year under the diagnosis of discoid lupus erythematosus. It recurred on the left cheek at 37 years of age.

Slightly reversed A/G ratio in serum was discovered. Histologic picture was typical.

Case 2 : A 18-year-old woman, a sister of case 1, found erythema with whitish pityriatic scales on the both cheeks. One month later the rashes were developed with fever, arthralgia and Raynaud's phenomenon.

She showed remission after systemic administration of adrenocortical steroids. Histologic picture was typical SLE. Marked increase of serum r-globulin was found.

As a mechanism of familiar occurrence of lupus erythematosus, there is a theory of transplac-entar transfer of LE factor or of hereditary dysproteinemia. In our cases abnormality in serum protein was proved, but the mechanism of familiar occurrence of them was difficult to be explained.

Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.


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