喉頭原発のsmall cell nenroendocrine carcinomaの1例

A Case of Small Cell Neuroendocrine Carcinoma of the Larynx

　はじめに

　喉頭原発のsmall cell neuroendocrine carcinoma（以下，SCNCと略）は比較的珍しい疾患といわれ，喉頭癌の0.5％を占める^1）。悪性度が高く，悪性リンパ腫，小細胞癌，類基底細胞癌，atypical carcinoid（以下，ACと略）との鑑別を要し，診断に免疫組織化学染色，電子顕微鏡所見を必要とする。

　今回われわれは，喉頭蓋より発生したSCNCの1例を経験したので，若干の文献的考察を加え報告する。

A 55-year-old male presented with laryngeal tumor in the supraglottic area of the larynx without distantmetastasis.

The diagnosis of small cell neuroendocrine carcinoma was made by light microscopic, electron microscopic and immunohistochemical findings. Partial laryngectomy and adjuvant radiation (total 54.6 Gy) were performed. Small cell neuroendocrine carcinoma has to be distinguished from atypical carcinoid. Differentiation between small cell neuroendocrine carcinoma and atypical carcinoid was discussed.