頭頸部MALTリンパ腫の2症例

Two cases of MALT lymphoma of the head and neck

Ⅰ　はじめに

　Mucosa-associated lymphoid tissue（MALT）リンパ腫は，通常ではリンパ組織の存在しない組織に発生するB細胞性リンパ腫であり，2001年のWHO分類^1）では濾胞辺縁帯B細胞性リンパ腫に分類されている。頭頸部領域は，消化器，肺に次ぐ好発部位とされているものの^2），その詳細についてはいまだ明らかにされていない点が多い。今回われわれは，耳下腺と上咽頭に発生したMALTリンパ腫の2症例を経験したので，本症例の病態を考察するとともに，報告する。

　We report two cases of mucosa-associated lymphoid tissue（MALT）lymphoma of the head and neck. The first case was a 21-year-old woman with Sjögren's syndrome who developed left-sided parotid MALT lymphoma. She underwent resection of the tumor with preservation of the facial nerve followed by 3 courses of chemotherapy consisting of rituximab,cyclophosphamide,doxorubicin,vincristine,and prednisolone. The second case was a 48-year-old man with epipharyngeal MALT lymphoma. He underwent resection of the tumor followed by 4 courses of rituximab administration and radiotherapy of 30 Gy. Complete remission was achieved in both patients,and no evidence of recurrence was observed in 20- and 12-month follow-up periods,respectively. The clinical characteristics,pathology and treatment of MALT lymphoma of the head and neck were bibliographically reviewed.