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Effect and dose-dependency of befunolol, beta-blocker, on the accommodative function Akemi Gotoh 1 1Dep. of Ophthalmol., Aichi Med Univ pp.119-123
Published Date 1986/2/15
DOI https://doi.org/10.11477/mf.1410209608
  • Abstract
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The effect of different concentrations of befunolol ophthalmic solution was evaluated on the accom-modative function in asthenopia. The study involved 27 eyes of 14 patients with asthenopia and 22 eyes of normal volunteers. 'Floating' accommodation and intraocular pressure were measured before and 30 minutes after instillation of 0.25%, 0.2%, 0.15% or 0.1% of befunolol.

In asthenopic subjects, floating accommodation sig-nificantly improved after instillation of 0.25% and 0.2% befunolol when compared 0.15% and 0.1% solutions (p<0.05).

No changes in floating accommodation were induced by befunolol of different concentration in nor-mal volunteers. The instillation failed to induce changes in intraocular pressure both in asthenopic and normal subjects. Baseline intraocular pressure was significantly higher in asthenopic subjects (16.6+5.7 mmHg) than in normal subjects (12.6-2.5 mmHg).

The findings indicate that topical befunolol improves accommodative function in subjects with asthenopia. The improvement in floating accommodation seemed to be related to initial intraocular pressure level.

Rinsho Ganka (Jpn J Clin Ophthalmol) 40(2) : 119-123, 1986


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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