奈良県立医科大学付属病院における未熟児網膜症の統計学的検討

Review of retinopathy of prematurity in Nara Medical University Hospital

要約　目的：未熟児網膜症の自験例の統計学的報告。対象と方法：2009年までの3年間に当院で診察した出生体重2,000g未満の新生児257症例を対象とし，未熟児網膜症の頻度と治療率，発症と治療に関係する重症化因子を検索した。結果：未熟児網膜症の発症は23.7％にあり，10.1％の症例が治療を必要とした。未熟児網膜症の発症例と非発症例との間には，在胎週数，出生体重，Apgarスコア1分値と5分値，脳室内出血につき，それぞれ有意差があった。結論：未熟児網膜症の発症と重症化には，網膜の未熟性とともに，脳血管の未熟性が関係していると推定される。

Abstract.　Purpose：To present a statistical review of retinopathy of prematurity（ROP）seen in our institution. Cases and Method：This retrospective study was made on 257 newborn infants with birthweight below 2,000 g during 3 years through 2009. Particular attention was paid to the incidence of ROP,cases needing treatment,and factors related to occurrence and severity of ROP. Results：ROP developed in 23.7％ and treatment was needed in 10.1％ of cases. There were significant differences in gestational age,birthweight,1-minute and 5-minute Apgar score,and incidence of cerebral intraventricular hemorrhage between cases with and without ROP. Conclusion：The findings seem to show that immaturity of retinal and cerebral vessels are involved in the onset and severity of ROP.