アテロコラーゲンによる涙道閉鎖―涙液減少症69例における臨床試験

Therapeutic occlusion of lacrimal duct by atelocollagen. Clinical evaluation on sixty-nine dry eye cases

　目的：体温でゲル化するアテロコラーゲン溶液を用いた涙道閉鎖処置の治療効果の評価。対象：Sjögren症候群26例を含む，涙液分泌減少症69例135眼。観察期間は8週間。結果：フェノールレッド糸法による涙液量は，処置直前と比較して処置後に有意に増加した（1週間目p＜0.005，4および8週間目p＜0.05；Wilcoxonの符号付順位検定）。フルオレセインスコアとローズベンガルスコアは処置後に有意に減少した（1，4および8週間目p＜0.0001）。他覚的評価および自覚的評価の両方において，56例（81.2％）で効果が確認された。結論：アテロコラーゲンによる涙道閉鎖処置は，涙液分泌減少症の治療の1つとして有用である。

　Purpose：To evaluate therapeutic occlusion of lacrimal duct by atelocollagen that turns into gel at body temperature. Cases and Method：A total of 136 eyes of 69 dry eye cases were treated for 8 weeks. The series included 26 cases of Sjögren syndrome. Findings were assessed by Wilcoxon signed-ranks test. Result：Compared with the pretreatment level,tear volume mesured by phenol-red thread increased after 1,4 and 8 weeks（p＜0.005,p＜0.05 and p＜0.05 respectively）. Fluorescein score and rose bengal score decreased after 1,4 and 8 weeks（p＜0.0001 each）. The outcome was categorized as very effective and effective by both objective and subjective evaluations in 56 cases（81％）. Conclusion：Occlusion of lacrimal duct by atelocollagen was useful for dry eye at least for 8 weeks.