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Safety and efficacy of unoprostone switched from latanoprost in patients with latanoprost-induced side effects Hiroko Kuga 1 , Osamu Miyauchi 1 , Naoya Fujimoto 1 , Eiju Sato 1 , Shuichi Yamamoto 1 , Norio Takeda 2 , Hiroko Yamazaki 3 , Yoshihiro Watanabe 4 , Kengo Amaya 5 1Dept of Ophthalmol and Visu Sci,Grad Sch of Med,Chiba Univ 2Dept of Ophthalmol,International Med Center of Japan 3Dept of Ophthalmol,Kohnodai Hosp Center of Neurol and Psychiatry 4Dept of Ophthalmol,Narita Red Cross Hosp 5Dept of Ophthalmol,Yohkaichiba Municipal General Hosp pp.1187-1191
Published Date 2004/7/15
DOI https://doi.org/10.11477/mf.1410100642
  • Abstract
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 We evaluated the safety and efficacy of unoprostone switched from latanoprost. The cases comprised patients that developed eyelid pigmentation or hypertrichosis as latanoprost-induced side effects. All had either primary open-angle glaucoma or normal-tension glaucoma. The intraocular pressure(IOP)was controlled below 20mmHg by latanoprost. Patients were followed up for 6months or longer after switching to unoprostone. Eyelid pigmentation was present in 19 eyes by photographic evaluation. It improved in 13 eyes after switching. Eyelid pigmentation was subjectively noticed in 11 eyes. It improved in 10 eyes after switching. Hypertrichosis was present in 13 eyes by photographic evaluation. It improved in 10 eyes after switching. Hypertrichosis was subjectively noticed in 7 eyes. It improved in 5 eyes after switching. There was no significant difference in visual acuity,IOP or visual field after switching. The findings show that eyelid pigmentation and hypertrichosis may improve by switching from latanoprost to unoprostone.


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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