ラタノプロストの副作用発現例のウノプロストンへの切り換えにおける有効性と安全性

Safety and efficacy of unoprostone switched from latanoprost in patients with latanoprost-induced side effects

　ラタノプロスト点眼の結果として眼瞼色素沈着または多毛が生じた症例をウノプロストン点眼に切り換え，その効果と安全性を検索した。全例が原発開放隅角緑内障または正常眼圧緑内障であり，眼圧が20mmHg以下にコントロールされていた。薬剤切り換え後の経過観察は6か月以上とした。眼瞼色素沈着は，写真判定で19眼にあり，うち13眼で改善した。自覚的な色素沈着は11眼にあり，うち10眼で改善した。多毛は写真判定で13眼にあり，うち10眼で改善した。自覚的な多毛は7眼にあり，うち5眼で改善した。視力，眼圧，視野の平均値は，薬剤切り換え後の経過観察で有意な変化はなかった。ラタノプロスト点眼で生じた眼瞼色素沈着と多毛が，ウノプロストン点眼に切り換えることで改善する可能性がある。

　We evaluated the safety and efficacy of unoprostone switched from latanoprost. The cases comprised patients that developed eyelid pigmentation or hypertrichosis as latanoprost-induced side effects. All had either primary open-angle glaucoma or normal-tension glaucoma. The intraocular pressure（IOP）was controlled below 20mmHg by latanoprost. Patients were followed up for 6months or longer after switching to unoprostone. Eyelid pigmentation was present in 19 eyes by photographic evaluation. It improved in 13 eyes after switching. Eyelid pigmentation was subjectively noticed in 11 eyes. It improved in 10 eyes after switching. Hypertrichosis was present in 13 eyes by photographic evaluation. It improved in 10 eyes after switching. Hypertrichosis was subjectively noticed in 7 eyes. It improved in 5 eyes after switching. There was no significant difference in visual acuity,IOP or visual field after switching. The findings show that eyelid pigmentation and hypertrichosis may improve by switching from latanoprost to unoprostone.