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Purine Catabolites and Pial Arteriolar Diameter in Transient Cerebral Ischemia Masao Tominaga 1 , Syozaburo Tsujimoto 1 , Toshikazu Takeshima 1 , Kazunori Miyamoto 1 , Yasuhito Ishida 1 , Masaya Nishitani 1 , Toshisuke Sakaki 1 1Department of Neurosurgery, Nara Medical University Keyword: purine catabolites , pial arteriole , microdialysis , free radicals , cerebral ischemia pp.807-812
Published Date 1992/9/1
DOI https://doi.org/10.11477/mf.1406900379
  • Abstract
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In transient cerebral ischemia, extracellular pur-ine catabolites and pial arteriolar diameter were measured continuously. Ischemia during one hour was induced by unilateral occlusion of left middle cerebral artery in feline. Extracellular purine catabolites were sampled by in vivo brain mi-crodialysis technique from the gray matter at ectosylvian gyrus. These catabolites were analyzedby HPLC system. Simultaneously, reactivity of pial arteriole was observed and its diameter was mea-sured through the cranial window using intravital microscope and width analyzer.

Extracellular concentrations of adenosine, inosine, hypoxanthine and xanthine were found to be 0.80±0.16μM, 2.01±0.95μM, 4.01±2.73μM and 3.93±2.39μM, respectively. During ischemia, the concentration of adenosine increased 8.7-fold and arteriolar diameter was 170% of the resting state. These findings in extracellular adenosine concentra-tion and pial arteriolar diameter during ischemia support a role of adenosine in regulation of cerebral blood flow.

After reperfusion, arteriolar diameter had return-ed to 120% of the resting state. But 50 min after reperfusion, pial arteriole began to dilate again coincident with the peak of xanthine concentration. These results suggest that free radicals were produced and could affect pial arterioles 50 min after reperfusion.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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