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〔目的〕片頭痛の病態生理は,未だ十分には解明されていないが,その発現には頭蓋内外の動脈の過拡張が一つの要因と考えられている。そこでわれわれは,片頭痛発作にて来院した9症例に頭痛発作時の局所脳血流量(rCBF)を測定しsumatriptan(イミグラン®)を投与し,その直後のrCBFを絶対値として測定した。
〔方法〕片頭痛発作時のrCBFとsumatriptan 3mg皮下注15分後のrCBFを連続的に99mTc-ECD background subtraction法にて絶対値として評価した。同時に血圧,心拍数の変化と症状の推移を観察した。
The present study was designed to examine the effect of sumatriptan on regional cerebral blood flow (CBF) during migraine headache.
Nine cases were examined by99mTc-ECD back-ground subtraction method for the absolute value measurement of regional CBF before and after sumatriptan injection. rCBF except for occipital and perioccipital lobes, were increased 10-20% during migraine headache and significant decreases were observed by sumatriptan injection.
Two cases of nine had transiently increased systemic blood pressure and cardiac pulse rate, however, all cases improved migraine headache after injection of sumatriptan.
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