Kainic Acid-induced Generalized Seizures in Cats : Microinjection into Caudate Nucleus Katsunobu Takano 1 , Tatsuya Tanaka 1 , Yukichi Yonemasu 1 1Department of Neurosurgery, Asahikawa Medical College Keyword: caudate nucleus , kainic acid , secondarily generalized seizure pp.719-725
Published Date 1992/8/1
DOI https://doi.org/10.11477/mf.1406900369
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Electroencephalograhic and behavioral changes were observed after 2pg of kainic acid (KA) injec-tion through a chronically implanted cannula into unilateral caudate nucleus (CN) of freely moving and non-anesthetized cats. The control group showed no changes on EEG or behavior during the observation period.

In KA group, from 2 to 5 minutes after KA injec-tion, the cats showed contralateral circling. On EEG, focal spikes were elicited at the injected site of the right CN. From 15 to 25 minutes after the injec-tion, secondarily generalized seizures were observed on EEG repeatedly. However, the behavioral change was not remarkable and only the behavioral arrest was observed during the electrographic generalizedseizure. From 6 to 8 hours after injection, they showed clonic seizure of the cotralateral hindlimb followed by generalized tonic-clonic convulsion. These seizures were frequent during 6 to 16 hours after injection. However, these seizures subsided within 48 hours after the injection and the cats became normal afterward. Histopathological exami-nation revealed focal pyknosis and gliosis only at the jnjection site of caudate nucleus.

The results suggested that an epileptogenic focus of the caudate nucleus demonstrated a rapid evolu-tion from the focal seizure status to the secondarily generalized seizure status. This fact explains that the caudate nucleus may be a possible key structure as a relay nucleus for the secondary generalization of a focal seizure.

Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.


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