EPIL EPTOGENIC PROPERTIES OF QUISQUALIC ACID:MICROINJECTION INTO THE UNILATERAL AMYGDALA IN CATS Mitsunobu Kaijima 1 , Tatsuya Tanaka 1 , Yukichi Yonemasu 1 1Department of Neurosurgery, Asahikawa Medical College pp.971-976
Published Date 1987/10/1
DOI https://doi.org/10.11477/mf.1406205993
  • Abstract
  • Look Inside

The present studies demonstrated that the microinjection of quisqualic acid (QA) into uni-lateral amygdala in chronically implanted cats re-sulted in various types of limbic seizures in ac-cordance with injected doses.

The epileptogenic potency of QA in the in-duction of epileptic seizures was lower then that of kainic acid (KA), which has also been demon-strated in our previous studies.

Electroencephalographic changes and clinical manifestations of QA-induced epilepsy were less prominent as compared with those of KA-induced epilepsy. Five micrograms of QA resulted in pure amygdaloid seizures. The moderate dose admini-stration of QA (15 pg) was suitable to observe limbic status. Both doses of QA elicited similar characteristic epileptic patterns on EEG, which was quite distinguishable from those of KA.

In pathological study, mild degeneration of hip-pocampal pyramidal cell layer was observed in the cases injected 15 pg of QA. These electro-clinical and pathological features are interesting in similar-ities to those of human complex partial seizures, mesial temporal sclerosis.

In conclusion, the strict dose dependency of QA in the production of limbic seizures is a valid advantage for an experimental model of a complex partial epilepsy in man.

Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院