Experimental Bilateral Focus Model of Complex Partial Seizure:Clinical, Electrophysiological and Pathological Studies Takahiro Maeda 1 , Kiyotaka Hashizume 1 , Masayuki Kunimoto 1 , Tatsuya Tanaka 1 , Yukichi Yonemasu 1 1Department of Neurosurgery, Asahikawa Medical College Keyword: experimental epilepsy , kainic acid , amygdala , spontaneous limbic seizure , bilateral focus pp.813-818
Published Date 1997/9/1
DOI https://doi.org/10.11477/mf.1406901162
  • Abstract
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Stereotactic surgery was performed in Wistar rats and stainless steel injection chemitrode were inserted in bilateral amygdala (AM).

Stainless steel screws were placed on the dura over bilateral motor cortex (Cx) . One week after the surgery, rats were placed in the recording cham-ber. Kainic acid (KA) injection was performed into the left AM and focal AM seizure status was in-duced. Seizures evolved into limbic seizure status during 3 days. Seven days after the first KA injec-tion, KA was injected into the right AM. The limbic seizure status was elicited again, however, these seizures subsided within 3 days.

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