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EFFECTS OF PHENOBARBITAL AND PHENYTOIN ON HIPPOCAMPUS GENERATING SEIZURES Yoshio Minabe 1 , Kenji Emori 1 , Masayoshi Kurachi 1 1Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University pp.1191-1194
Published Date 1989/12/1
DOI https://doi.org/10.11477/mf.1406206439
  • Abstract
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We have recently reported some pharmacologi-cal studies using a kindling model of epilepsy in-duced with 1-3 HZ electrical stimulations, referred to as the low-frequency kindling. Since a previous study showed that the effects of psychotropic drugs on limbic seizures were dependent on the location of epileptic focus, we decided to study acute and chronic effects of anticonvulsants on the hippocam-pus generating seizures to compare with the results of a previous study of the amygdala generating seizures, which was done under the same condi-tions with this study. The number of stimulating pulses required for the triggering of epileptic af-terdischarge (pulse-number threshold) was used as the indicator for the seizure threshold. Duration of afterdischarge (ADD), ictal and interictal beha-viors of the subjected 7 cats, and serum drug levels were also recorded.

A dose-dependent increase of serum drug levels was confirmed in each drug, and the values were well comparable with the optimal range in clinical use. In acute experiment PB 5 mg/kg p. o. produ-ced no significant effect on PNT and ADD. PB 10 mg/kg increased PNT significantly (p<0. 02) at 2 hrs after administration without affecting ADD, but 4 cats presented the seizure-stage regressions. PB 20 mg/kg increased PNT (p<0. 02) and decre-ased ADD (p<0. 02) with the seizure-stage regres-sions of all the tested cats at 2 hrs after administra-tion, and increased PNT (p<0. 05) without affect-ing ADD and seizure stage at 96 hrs after admini-stration. PHT 5, 10, 20 mg/kg decreased PNT (p <O. 05, 0. 02, 0. 02, respectively) without affecting ADD at 2 hrs after administration. In chronic experiment (10 mg/kg/day p. o., 14 days), PB and PHT showed the same pharmacological features with those of acute experiment.

We compare the results of this study with those of a previous study of amygdala generating seizu-res. 1, PB produced a PNT-increase more promi-nently than decreases of ADD and seizure stage at 5 and 10 mg/kg in amygdala seizure, suggesting that PB produced the same anticonvulsive action on the two limbic seizures. 2, Whereas PHT de-creased ADD and seizure stage without affecting PNT at 15 and 30 mg/kg/ in amygdala seizure, PHT produced only a proconvulsive action by de-creasing PNT in hippocampus seizure. Previous stu-dies showed that the inhibitory effect of anticon-vulsants on seizure threshold and ADD varied be-tween individual brain structures. However we do not know other studies which well described that anticonvulsants exerted different actions between hippocampus-and amgdala-generating seizures.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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