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Japanese

A Study on the Protective Mechanism of Phenytoin in Transient Global Ischemia Kyuzo KUROSAWA 1 , Shigeki IMAIZUMI 1 , Hiroyuki KINOUCHI 1 , Takashi YOSHIMOTO 1 , Jiro SUZUKI 1 1Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine Keyword: Phenytoin , Na-K ATPase , Transient global ischemia pp.427-434
Published Date 1989/5/10
DOI https://doi.org/10.11477/mf.1436202815
  • Abstract
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Ischemia gives rise to severe energy depletion and imbalance of Ca2+ homeostasis. This condition leads to activation of phospholipases A2, A1 and to attenuation of ATP dependent reacylation. As a result, free fatty acid (FFA) especially arachidonic acid accumulates. Phenytoin has been reported to blockade the various Ca2+ channels. In this study, we could investigate the effect of phenytoin on the liberation of FFA, energy metabolites, various nucleotides metabolism, Na+, K+-ATPase activity, and water and electrolyte contents in the ischemic brain


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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