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Japanese

A TRIAL OF ACNU AND RADIATION THERAPY WITH SENSITIZING AGENTS FOR MALIGNANT GLIOMAS Hirokazu Kawano 1 , Minoru Hayashi 1 , Kazufumi Satoh 1 , Hisamasa Ishii 1 , Shigekazu Nakatsugawa 2 , Yasushi Ishii 2 1Department of Neurosurgery, Fukui Medical School 2Department of Radiology, Fukui Medical School pp.1071-1075
Published Date 1989/11/1
DOI https://doi.org/10.11477/mf.1406206419
  • Abstract
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Twelve cases of malignant gliomas (anaplastic astrocytoma 4, glioblastoma 8, recurrent 3, primary 9) were treated with ACNU and radiation with sensitizing agents after the surgical removal of the tumor. BUdR, Vidarabine (Ara-A), Aciclovir (ACV) were applied for sensitizing agents. BUdR was administrated intraarterially prior to radiation (380 rad, two times a week), and Ara-A and ACV intravenously during and after the radiation. Total dosage of the radiation was 50-60 Grey for each case.

All recurrent and eight primary patients died. The mean survival time of the recurrent patients was 17.7 months, while that of the primary pa-tients was 13.4 months. One of the primary pa-tient was glioblastoma and is still surviving more than 24 months by now. The complete response (CR) rate of the primary tumor patients observed by computerized tomography (CT) scan was 5/9. We can expect the availability of this trial for malignant gliomas because of high CR rate in pri-mary tumor cases.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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