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NON-VERBAL FACIAL AND TOPOGRAPHIC VISUAL OBJECT AGNOSIA: A PROBLEM OF FAMILIARITY IN PROSOPAGNOSIA AND TOPOGRAPHIC DISORIENTATION Nobuyoshi Takahashi 1 , Mitsuru Kawamura 1 , Keizo Hirayama 1 , Koichi Tagawa 2,3 1Department of Neurology, Brain Research Institute, School of Medicine, Chiba University 2Division of Neurology, Research Institute for Brain and Blood Vessels-Akita pp.703-710
Published Date 1989/7/1
DOI https://doi.org/10.11477/mf.1406206355
  • Abstract
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In recent years, prosopagnosia is defined as the "loss of ability to recognize the well-acquainted persons like the family members by their physio-gnomy." There are many reports based on this definition. However, from the viewpoint of symp-tomatology, there are many problems not entirely solved yet. And the mechanism of its manifesta-tion is not clearly explained. Topographic disori-entation, which often accompanies prosopagnosia, is studied even less. From the results of the post-mortem examination in the literature, bilateral occipito-temporal lesions have been known to cause prosopagnosia. However, the recent radio-graphical examination by the computed tomography revealed that the prosopagnosia is also caused bythe right occipito-temporal lesions only.

We experienced a case with prosopagnosia and topographic disoriention which were considered to be caused by infarction in the territory of the right posterior cerebral artery.

Detailed symptomatological, morphological and functional examinations were carried out by means of various psychological testing, X-ray computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET).

The patient was a 70-year-old right-handed man who suffered from sudden visual loss on both eyes, and was admitted to our hospital after four weeks. On examination, a decrease of visual acuity and right homonymous hemianopsia were recognized. When visual acuity was recovered, he was unable to recognize the faces of his relatives and friends, with whom he has been well acquainted for many years. He also found his own house, the buildings and streets around it as entirely unfamiliar.

Seven months after the onset of the disease, ex-amination showed he had definite prosopagnosia and topographic disorientation. He also neglected the left half of space and the disturbance of con-structive behavior was noticed. WAIS showed verbal IQ 115, performance IQ 62 and general IQ 96. By the detailed symptomatological study, we summarized the features of this case in the follow-ing four points : ( 1 ) The patient suffered from prosopagnosia, unable to identify the physiogno-my of the persons whom he should be able to re-cognize. The patient was also unable to remember the physiognomical image of his family members,but he could describe the features of the physio-gnomical components of their faces (such as eyes, nose, mouth, etc.). ( 2 ) He was able to identify the unfamiliar faces. ( 3 ) The patient could recognize and identify facial expressions, age, sex and beauty or ugliness. ( 4 ) As for the topographic disori-entation accompanying prosopagnosia, he was un-able to identify the buildings and street scenes in the photographies, which he should be familiar with, but the so-called disorder of topographical memory was not noticed.

Radiographic examination by the computed to-mography revealed the lesion on the lower inside of right temporal and occipital lobe as a low den-sity area. By MRI, the lesion was also limited to the same area, more specifically in the fusiform and lingual gyri. The functional examination by PET showed no definite lesion in the left cerebral hemi-sphere.

Based on the results of these examinations to-gethere with the data in the literature, we reached the following conclusions : ( a ) The agnosias of the familiar faces and the unfamiliar faces are considered to be caused by the different mecha-nisms. ( b ) It is suggested that the prosopagnosia is caused by the disturbance of the physiognomical memory or by the disconnection between morpho-logical recognition for physiognomy and its memo-ry, rather than the disturbance of recognition itself. ( c ) The right fusiform and lingual gyri are considered to be most important in prosopa-gnosia.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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