Japanese

COMPARISON OF TWO DIMENSIONAL AND THREE DIMENSIONAL CBF MEASUREMENTS IN STROKE PATIENTS Tohru Yamada 1 , Takeshi Shima 1 , Shigejiro Matsumura 1 , Yoshikazu Okada 1 , Masahiro Nishida 1 , Kanji Yamane 1 1Department of Neurosurgery, Chugoku Rousai Hospital pp.375-381
Published Date 1989/4/1
DOI https://doi.org/10.11477/mf.1406206295
  • Abstract
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The purpose of this study is to compare the detectability of the reduction in cerebral blood flow (CBF) using the two versus the three dimensional technique of CBF measurement. Both techniques were simultaneously carried out 85 times on 52 stroke patients.

In the two dimensional technique, CBF was mea-sured by the Xe-133 inhalation method and the value was calculated by the initial slope index. In the three dimensional technique, CBF was mea-sured by single photon emission CT with Xe-133 inhalation method. CBF reduction was studied in the middle cerebral artery (MCA) territory on a CBF map in both techniques. Additionally, mean CBF was also calculated for the same territory. On the CBF map, the CBF reduction was shown in 25 of 85 measurements with the two dimensionaltechnique and in 41 of 85 with the three dimension-al technique. In comparing the imagings of both techniques, the CBF reduction seen extensively along the cortical surface and in the entire MCA territory with the three dimensional technique was also detected with the two dimensional technique. However, focal CBF reduction observed at the cortical surface and in the deep cerebral tissue with the three dimensional technique was not de-tected with the two dimensional technique.

In order to evaluate both techniques quantita-tively, we calculated the ratio of the mean CBF difference between the MCA territories of both hemispheres to mean CBF in the non-affected MCA territory. This ratio represented the asym-mentry index. Firstly, the relationship between asymmetry index and the imaging of CBF reduc-tion on the CBF map was studied. All measure-ments except one with abnormal asymmetry in-dices showed CBF reduction on the CBF map. This suggests that qualitative findings from the CBF map correspond to the quantitative results of the asymmetry index calculation. Secondly, the asymmetry index calculations using the two di-mensional versus the three dimensional technique were compared. The case with the higher asym-metry index value measured with the three dimen-sional technique also showed a corresponding higher value with the two dimensional technique. However, the case with the smaller index value measured with the three dimensional technique did not show a corresponding value with the two di-mensional technique. This suggests that the two dimensional technique can not quantitatively detect a small reduction in CBF.

The three dimensional technique of CBF mea-surement was superior to the two dimensional technique not only with respect to imagings of CBF reduction on the CBF map, but also for quantitative determination based on the asymmetry index calculation. The limitations of the two di-mensional technique as shown in the present qual-itative and quantitative studies were considered to be largely due to "cross talk". These results sug-gested that the limitations of the two dimensional technique should be considered when using this technique clinically.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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