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THE METABOLIC RESPONSE IN ACUTE STAGE OF CEREBRAL INFARCTION: WITH SPECIAL REFERENCE TO OXYGEN CONSUMPTION AND RESTING METABOLIC EXPENDITURE Hajime Touho 1 , Tohoru Sawada 2 , Jun Karasawa 1 , Haruhiko Kikuchi 3 , Shigeki Ohgitani 4 1Department of Neurosurgery, Osaka Neurological Institute 2Department of Internal Medicine, Cerebrovascular Division, National Cardio-vascular Center 3Department of Neurosurgery, National Cardio-vascular Center 4Clinical Laboratory, National Cardio-vascular Center pp.481-486
Published Date 1986/5/1
DOI https://doi.org/10.11477/mf.1406205710
  • Abstract
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 Oxygen consumption, carbon dioxide production, respiratory quotients, and resting metabolic expenditure were measured in 23 patients with cerebral infarction in their acute stage. Metabolic measurement were carried out with the technique of indirect calorimetry on their admission within two days from the onsets. At the same time, urine was collected twenty-four hours to measure urinary catecholamine excretion. Mean value of resting metabolic expenditure was 115.1% and this positively correlated with urinary catecholamine, especially noradrenaline excretion. Maximum value of resting metabolic expenditure was up to 187. 1% of that expected for an uninjured resting person of equivalent age, sex, and body surface area. Oxygen consumption and carbon dioxide production also positively correlated to urinary catecholamine excretion. On the other hand, respiratory quotients did not have any significant correlation with oxygen consumption, carbon dioxide production, resting metabolic expenditure, or urinary catecholamine excretion.

 From those facts, it was implied that overactivity of sympathetic nervous system existed in their acute stage of cerebral infarction, and the overflow might directly influence oxygen consumption, carbon dixide production, and resting metabolic expenditure, and moreover we had to take into consideration of hyper-metabolic state to manage patients with ischemic cerebrovascular diseases as malnutrition might cause weight loss and immune incompetence.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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