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MBP, GFAP IMMUNOHISTOCHEMISTRY OF OLIGODENDROGLIOMAS WITH RELATIONSHIP TO MYELIN-FORMING GLIA IN THE CELL DIFFERENTIATION Yasuo Hokama 1 , Junichi Tanaka 2 , Haruomi Nakamura 2 , Tomokatsu Hori 1 1Divisions of Neurosurgery, Institute of Neurological Sciences, Tottori University School of Medicine 2Divisions of Neuropathology, Institute of Neurological Sciences, Tottori University School of Medicine pp.379-386
Published Date 1986/4/1
DOI https://doi.org/10.11477/mf.1406205695
  • Abstract
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The histologic feature of oligodendroglioma isconstituted by the monotonously arranged sheets of tumor cells intersected with delicate vascular stroma. The shape of the tumor cells is usually uniform and occasionally rather pleomorphic. In order to clarify biological characteristics of the tumor cells at level of cell differentiation, immuno-histochemical stains for myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) with PAP method were performed on 13 oligo-dendrogliomas obtained by surgical removal. The cells stained positive with MBP immunostain were encountered in 5 tumors and their incidence was ranging from 1 % to more than 30 % of all tumor cells. The MBP-positive cells were chara-cterized by having a large clear nucleus with a prominent nucleolus and relatively abundant cytoplasm, that seemed to mimic myelin-forming glia appearing in normal developing brain. The cells with poor cytoplasm or surrounded by a perinuclear halo were MBP-negative, and the pleomorphic cells in majority of anaplastic oligo-dendrogliomas were also negative. On the other hand, with GFAP stain the positive cells were observed in 8 tumors. It is still controversial to interpret the occurrence of GFAP-positive cells in oligodendrogliomas. In this study the GFAP-positive cells were morphologically identical to the MBP-positive cells, so that both MBP and GFAP are supposed to exist in the same tumor cells. It is assumed that some of oligodendro-glioma cells which showed such immunostainabili-ties could possess an intrinsic character to express a phenotype of myelin-forming glia. Possibly, MBP substance is applicable as one of immunohi-stochemical markers for oligodendroglioma cells to indicate a certain cell differentiation.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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