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POTENT CONVULSANT EFFECTS OF A BENZODIAZEPINE INVERSE AGONIST, METHYL β-CARBOLINE-3-CARBOXYLATE IN CATS Mitsunobu Kaijima 1 , Robert Dodd 2 , Esper Cavalheiro 2 , Lia Prado de Carvalho 2 , Jean Rossier 2 , Robert Naquet 2 1Department of Neurosurgery, Asahikawa Medical College pp.797-803
Published Date 1984/8/1
DOI https://doi.org/10.11477/mf.1406205367
  • Abstract
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The convulsant properties of methyl β-carbo-line-3-carboxylate β-CCM), which is a homologue of a putative benzodiazepine receptor ligand in the mammalian central nervous system, were ex-amined in cats.

Subcutaneous injection of 0.5 mg/kg of the β- CCM produced various degrees of myoclonic jerks always accompanied by cortical spike burst. Some autonomic symptomes such as tachypnea, hyper-secretion of thick mucous saliva, vomiting and mydriasis were also presented.

Subcutaneous injection of 1.0 mg/kg of the com-qound induced a generalized tonic-clonic convul-sion. Injection of the same amount of the drug 1 hour later in the same cats failed to provoke a generalized seizure. Repeated injection of the same dose 3 hours later provoked a generalized seizure, but with a longer latency. However, repetition of the experiments 24 hours after or 10 days after the first injection consistently induced the same type of generalized seizure with the same latency as the first injections.

These results support the suggetion that the pharmacological effect, especially the convulsive effect, of β-CCM is dose-related, reversible and reproducible in the same cats and among different cats. Moreover, the postictal refractory period in this model of epilepsy may continue about for 3 hours.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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