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NEURONAL DEVELOPMENT OF THE FETAL AND INFANTILE PERIOD : 1.VISUAL CORTEX IN THE NORMAL AND CHROMOSOMAL ABERRATIONS Sachio Takashima 1 1Division of Child Neurology, Tottori University Medical School pp.1007-1013
Published Date 1980/10/1
DOI https://doi.org/10.11477/mf.1406204652
  • Abstract
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A quantitative and qualitative study of the deve-loping occipital cortex was done in the humans from 14 weeks gestation to six months after birth,and chromosomal aberrational neuronal develop-ment was compared with normal development.

Case materials and methods: 37 human brains (neurologically normal 27, Down syndrome 8 and trisomy 13 syndrome 2 cases) were studied, rang-ing in age from 14 weeks gestation to 6 months of age. At autopsy a 5mm slice of the right visual cortex was cut from the unfixed brain and rapid Golgi study was done. The number of spines was counted in 25 micron segments along the apical and basal dendrites of pyramidal neurons of the fifth and third layers.

A section adjacent to the area prepared for Golgi impregnation was used for neuron counting within each column (50×250 microns) of cortex on the Nissl stain.

Results At 20 weeks of gestation several spines were seen on the apical and basal dendrites of small pyramidal neurons and the density of spines is greater in the proximal than in the distal parts of the apical and basal dendrites. Biporal neurons were persistent until 28 weeks gestation. With aging the number of spines gradually increased in the distal parts of the apical and basal dendrites. but was smaller in the proximal parts.

In Down syndrome (20 GW~2M) and trisomy 13 syndrome the number and development of spine did not show any significant difference from those in the normal group, but spines were shorter in Down syndrome and were thinner and longer in trisomy 13 syndrome than those in normal group.


Copyright © 1980, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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