完全虚血脳灌流モデル犬

A CANINE MODEL OF COMPLETE ISCHEMIC BRAIN REGULATED WITH PERFUSION METHOD

I．はじめに

　虚血脳の病態生理を知る目的で，多くの研究者が，いろいろの実験モデルを用いて検討を行なつてきたが，従来の血管遮断モデル^{1〜3,6,7,10〜12,14,15,17,18）}やembolization法^13,16,19）などでは，虚血巣の発生頻度が低く，またその部位や大きさも不定であり，しかもその程度をコントロールすることが困難であり，完全虚血巣の作製に到つては，実験者の夢でさえあつた。

　また，完全，不完全を問わず，臨床治療法に直結する血流再開による脳の病態の解明は，完全虚血脳を作製して，そこに血液，あるいは，薬液を自由にコントロールしながら灌流できるモデルを作ることによつてこそ，初めて正確な結果が得られるのである。

A model of complete ischemic brain regulated with a perfusion method in dogs was produced by interrupting the main arteries at the base of the brain and perfusing the arterial blood from the femoral artery of the dog to the lt. hemisphere through a tube cannulated into the rt. M. C. A. retrogradely. The cerebral blood flow in the lt. hemisphere is regulated by the infused blood volume which can be regulated with a pump.

Hyperemic brain, normal brain, incomplete ischemic brain and complete ischemic brain can be produced in the entire lt. hemisphere at will in all dogs. Recirculation is also possible by means of the regulation of blood flow after various degrees of ischemia.

This model also allows for the study of the various effects of drugs on the ischemic brain and research on the sequential pathological and chemical changes without individual defferences among the dogs.

This model should be valuable for investigation of not only ischemia but also cerebral metabolism, cerebral pharmacology and cerebral blood circu-lation.