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Brain and Nerve No to Shinkei Volume 32, Issue 9 （September 1980）

Brain and Nerve 脳と神経 32巻9号（1980年9月発行）

Japanese English

原著

Parkinson病治療中出現した精神症状について A STUDY ON MENTAL SYMPTOMS DEVELOPED DURING THE TREATMENT OF PARKINSON'S DISEASE 井手下久登 ^1,2 , 森田博方 ¹ , 好永順二 ¹ , 佐々木高伸 ¹ , 引地明義 ¹ Hisato Ideshita ^1,2 , Hironori Morita ¹ , Junji Yoshinaga ¹ , Takanobu Sasaki ¹ , Akiyoshi Hikiji ¹ ¹社会保険広島市民病院神経科 ²現籍：広島大学医学部神経精神医学教室 ¹Department of Neurology, Hiroshima City Hospital pp.941-947

発行日 1980年9月1日 Published Date 1980/9/1

DOI https://doi.org/10.11477/mf.1406204643

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Abstract 文献概要
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　Parkinson病治療中に出現する精神症状のため治療を中断せざるを得ない場合が少なくない。その種類，出現頻度についての報告はかなりみられるが，詳細な症状の記述，出現に関係する因子などについての検討はほとんど行われていない。

　われわれはParkinson病101例（男39例，女62例）の治療中に出現した精神症状を検討し，23例に幻覚，妄想，せん妄状態を認め，その内容により症例を次の3種類に分類した。1）体験中，意識障害がほとんど認められず，視覚体験の変化^10）（幻視，錯視，実体的意識性^11），変形視）を主症状とする症例，2）体験中，意識障害がほとんど認められず，妄想を主症状とする症例，3）せん妄状態を呈する症例。

We studied on mental symptoms which developed during the treatment of Parkinson's disease. Hallucination, delusion, and/or delirious state were observed in 23 (22.8%) of 101 cases. The cases with mental symptoms were studied for the incidence, detail of the symptoms, and the factors involved in their development.

Result:

1) Mental symptoms were observed in 23 patientsand the incidence tended to be highest in the patients in their sixties.

2) In classification of the cases with mental symptoms, 12 cases showed the change of visual experience as main symptom and 3 cases had delusion. In these two classes, disturbance of consciousness was minimum, if any. Eight cases showed delirious state.

3) As for mental symptoms, visual hallucination was most frequently observed.

4) Complication of hypertension and history of depressive state were more frequently observed in the cases with mental symptoms than in those without.

5) Mean daily dose of L-dopa upon the onset of mental symptoms was less than mean dailymaximum dose in the cases without mental symptoms.

6) The cases with cerebral atrophy in CT had a tendency to develop mental symptoms.

7) The cases with abnormal EEG were liable to develop mental symptoms.

8) The cases with mental symptoms were more often complicated by dyskinesia than those without.

Conclusion:

The incidence of mental symptoms during the treatment of Parkinson's disease tended to be high in the aged patients who had all or some of these findings as previous history of psychiatric illness, hypertension, cerebral atrophy and abnormal EEG.