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MECHANISM OF CONTRAST ENHANCEMENT ON COMPUTED TOMOGRAPHY IN CEREBRAL INFARCTION : REGIONAL CEREBRAL BLOOD FLOW, FLUORESCEIN ANGIOGRAPHY, AND PATHOLOGlCAL STUDY Takeshi Kawase 1 , Masahiro Mizukami 1 , Hiroshi Kin 1 , Toshiki Takemae 1 , Gorō Araki 2 1Department of Neurosurgery, Institute of Brain and Blood Vessels, Mikara Memorial Hospital 2Department of Internal medcine, Institute of Brain and Blood Vessels, Mikara Memorial Hospital pp.1121-1129
Published Date 1978/10/1
DOI https://doi.org/10.11477/mf.1406204322
  • Abstract
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Thirty-five patients with cerebral infarction were studied with serial computed tomography (CT). The patients with a small infarction located in the basal ganglia or the brain stem were excluded. Regional cerebral blood flow (rCBF) was also inves-tigated in 24 patients by the 133Xe intracarotid injection method, and thirteen of them had rCBF study when CT showed positive contrast enhance-ment (CE). Additional three patients, who had shown positive CE, underwent surgery, and fluorescein cortical angiography (FCA) was per-formed at operation in two patients, and patho-logical specimen was obtained in one patient.

More than 90 percent of the patients with infarction showed positive CE, mostly 10 days to one month of stroke. The quantitative value of enhancement in the lesion was 5 to 22 times (average 9 times) higher than that of the opposite normal hemisphere. rCBF values of enhanced area were significantly higher (49.7±12.7m//100 g/min.) than that of the area where showed no enhance-ment on CT (29.0±9.3ml/100 g/min.). However, hyperemic regions were seen only in four patients, and two of them showed no enhancement on CT. This fact does not agree with the hypothesis that positive CE indicates a manifestation of the focal hyperemia. FCA showed extravasation of fluores-cein dye in the perivascular spaces. Microscopic examination of specimen revealed numerous lipid-laden microglias and capillaries in the infarcted area, particularly at the edges of the infarct.

These findings suggest that the positive CE in cerebral infarction may be caused by extravasation of contrast material by opening the blood brain barrier of newly formed or dilated vessels in the infarcted area.


Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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