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Japanese

EXPERIMENTAL BRAIN TUMORS PRODUCED TRANS-PLACENTALLY BY ETHYLNITROSOUREA (IV) : ULTRA-STRUCTURE STUDIED BY USING TRANSMISSION AND SCANNING ELETRON MICROSCOPE Katsushi Taomoto 1,2 , Kiyoshi Fujiwara 1,2 , Norihiko Tamaki 1,2 , Satoru Matsumoto 1,2 1Department of Neurological Surgery, Kobe Universisy School Medicine pp.911-921
Published Date 1978/8/1
DOI https://doi.org/10.11477/mf.1406204294
  • Abstract
  • Look Inside

The fine structure of rat gliomas induced trans-placentally with a single i.p. does of 50 mg/kg of Ethylnitrosourea has been studied by using trans-mission and scanning electron microscope.

The subependymal matrix layers of the fetus which was affected by ENU have showed irregular and rough arrangements with expanded extracellular spaces as compared with that of control rats.

The cells of subependymal layer seemed to form the microtumor. A so-called "microtumor", which was found in a 8 week old, has been composed of small round cells. The fine structures of these cells have showed the characteristics in primitive oligo-dendroglioma.

The characteristics of the fine structure of astro-cytoma cells was identified by both TEM and SEM. The fine structure of subependymal glioma cells was often pleomorphic. These gliomas contained a mixture of primitive oligodendrocytes and epen-dymal cells together with anaplastic glial cells. With increasing size, the glioma has become more pleomorphic with a mixture of neoplastic oligo-dendrocytes, astrocytes and ependymal cells, and ependymoma like cells have showed neither cilia nor junctional complex.

Abnormal vascular structure in the tumor has been reconfirmed by injection replica scanning elec-tron microscope method.

The fine structure of the separated single tumor cell surface was also studied by scanning electron microscope. The differences of the cells surface between that of astrocytoma cell and oligodendro-glioma cells were clearly noticed.


Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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