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Brain and Nerve No to Shinkei Volume 30, Issue 4 （April 1978）

Brain and Nerve 脳と神経 30巻4号（1978年4月発行）

Japanese English

原著

リチウム慢性中毒犬における脳内リチウム分布とインドールアミン代謝について LITHIUM DISTRIBUTION AND REGIONAL INDOLEAMINE METABOLISM IN THE DOG BRAIN WITH PROLONGED LITHIUM INTOXICATION 光信克甫 ¹ , 江原嵩 ¹ , 渡辺昌祐 ² , 黒田重利 ¹ , 大下俊則 ¹ , 長尾卓夫 ¹ , 末光茂 ¹ , 鍋山敏朗 ¹ , 大月三郎 ¹ Katsusuke Mitsunobu ¹ , Takashi Ebara ¹ , Shosuke Watanabe ² , Shigetoshi Kuroda ¹ , Toshinori Oshimo ¹ , Takuo Nagao ¹ , Shigeru Suemitsu ¹ , Toshiro Nabeyama ¹ , Saburo Otsuki ¹ ¹岡山大学医学部神経精神医学教室 ²川崎医科大学精神医学教室 ¹Department of Neuropsychiatry, Okayama University Medical School ²Department of Psychiatry, Kawasaki Medical College pp.393-398

発行日 1978年4月1日 Published Date 1978/4/1

DOI https://doi.org/10.11477/mf.1406204229

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Abstract 文献概要
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I．はじめに

　リチウム（Liと略記す）イオンのindoleamine （IAと略記す）に与える影響については多くの報告がなされているが，その結果は必ずしも一定していない。すなわちLiは脳5—hydroxytryptamine （5 HTと略記す）濃度や5—hydroxyindoleacetic acid （5 HIAA　と略記す）濃度を増加するとの報告もある一方，Liにより5HTや5HIAA濃度が減少するとの相反する結果もあり，さらにLiにより脳5HT代謝は影響を受けないとの報告もある，

　われわれは，以前ネコ脳灌流実験法を用いてナトリウム（Naと略記す）イオンをLiで置換した条件で脳tryptophan,5HTおよび5HIAA濃度を測定し，脳内IA代謝が抑制されたことを報告した^7）が，このたび犬に慢性的に炭酸Liを投与し中毒状態に置いた後に，脳部位別にLi,5HTおよび5HIAA濃度を測定し，Liの慢性中毒濃度下における脳内IAの変化について調べた。

After the serious lithium (Li)-intoxication had been maintained by the chronic administration of Li carbonate to dogs, the regional distribution of Li and the changes of regional 5-hydroxytryptamine (5HT) and 5-hydroxyindoleacetic acid (5HIAA) levels were examined.

Li was administered for 39-77 days (average 52days) and 38-140 days (ay. 110 days) for the study of Li distribution and indoleamine study, re-spectively. In the former, dogs died 10-48 days (ay. 26 days) after the onset of serious Li-intoxi-cation. In the latter, all dogs were necropsied after 25-110 days (ay. 60 days) of serious intoxication. Li doses, at the time of brain autopsy, were 50-110 mg/kg/day (ay. 80 mg/kg/day) and 110-140 mg/ kg/day (ay. 117 mg/kg/day), respectively.

1. Li was distributed unevenly in the brain. The amygdala, thalamus and hippocampus obtained the highest; the inner capsule, diencephalon, midbrain, cerebral gray matter, cerebral white matter, medulla and pons showed intermediate, whereas the other regions such as cerebellum and spinal cord demonstrated the lowest concentration of Li. There were considerable variations in Li-tolerance according to individual dogs.

2. 5HT levels were decreased significantly in the medulla (to 55% of the control), cerebral gray matter (to 63%) and white matter (to 75%), and 5HIAA levels were decreased significantly in the pons (to 17%), lenticular nucleus (to 42%), cere-bellum (to 42%) and inner capsule (to 63%).

3. No correlations were seen between the Li ion concentration and the extent of the regional 5HT and 5HIAA decrease.

These results suggest that 5HT and 5HIAA levels decrease during the prolonged Li-intoxication and the extent of their decrease does not depened on the Li concentration but on the biological specificity of the brain regions.