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Brain and Nerve No to Shinkei Volume 30, Issue 1 （January 1978）

Brain and Nerve 脳と神経 30巻1号（1978年1月発行）

Japanese English

原著

"周期性発作性発射"の時間間隔の検討 TIME INTERVAL ANALYSIS OF"PERIODIC EPILEPTIC DISCHARGES" IN HUMAN EEGs 一条貞雄 ¹ , 渡辺浩崇 ² , 力丸庄蔵 ³ , 宮腰孝 ⁴ Sadao Ichijo ¹ , Hirotaka Watanabe ² , Shozo Rikimaru ³ , Takashi Miyakoshi ⁴ ¹仙台鉄道病院神経科 ²東北大学医学部鳴子分院内科 ³東北大学医学部脳研脳神経内科 ⁴東北大学医学部神経精神科 ¹Department of Neuropsychiatry, Sendai Railway Hospital ²Department of Medicine, Narugo Branch of University Hospital, Tohoku University chool of Medicine ³Division of Clinical Neurology, Institute of Brain Disease, Tohoku University School of Medicine ⁴Department of Neuropsychiatry, Tohoku University School of Medicine pp.91-97

発行日 1978年1月1日 Published Date 1978/1/1

DOI https://doi.org/10.11477/mf.1406204191

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Abstract 文献概要
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I．はじめに

　脳波上に棘波や鋭波あるいは複合波のような発作性の発射（discharges）が，およそ1ないし数秒位の時間間隔で"周期性（periodic）"にくり返して現われることがあり，その発現機序について多くの興味がもたれて来た。しかし，それについてまだ十分に解明されているとはいえず，今回，そのような発射の示す時間間隔を計測し，ここではまず時間的出現様式を検討することにした。

Time intervals of epileptic discharges in human EEGs were analyzed. The subjects were 4 patients of various diseases showing "periodic discharges"in EEG with relatively regular intervals, and 3 epilepticus showing epileptic discharges with ir-regular intervals. The intervals of 60 to 300 con-secutive discharges were measured manually. The interval histograms were plotted and the cumulative distribution curves were also written. There were, at least, two different types of"periodic dis-charges".

The first type of periodic discharges was seen in Creutzfeldt-Jakob disease, for example, and single repetitive spike or sharp waves occurred at an interval of about 0.5 to 2 sec. The interval histograms of this type, however, did not neces-sarily show a normal distribution but a skewed one towards longer interval direction. In a clinical course of Creutzfeldt-Jakob disease, it was observed that the interval of discharges changed to be longer and irregular. Cortical lesion primarily was sup-posed for producing this type of periodic patterns.

The second type was seen in the subacute sclero-sing panencephalitis ("SSPE") and the EEG showed bilaterally synchronous, periodic bursts consisted of sharp and slow waves. The time intervals were about 3 to 8 sec. The time interval histograms of this type showed normal distribution curves and in a clinical course the pattern of this distribution remained stable. The mechanisms for producing this type of periodic discharges were discussed in terms of the thalamus or the upper brain-stem.