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ANALYSIS OF TUMOR GROWTH IN RECCURRENT MALIGNANT GLIOMAS Masao Matsutani 1 , Takao Hoshino 1 1Department of Neurosurgery, Faculty of Medicine, University of Tokyo pp.277-281
Published Date 1975/3/1
DOI https://doi.org/10.11477/mf.1406203674
  • Abstract
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In seven cases of recurrent malignant gliomas treated by extensive removal, the rate of cell growth was analysed in terms of their cell cycle time. On the assumption that the residual cell population is 108 at the time of operation and the growth fraction is 0.3, the range of cell cycle time wascalculated to be 2-3 days. In some cases treated with irradiation and/or chemotherapy after extensive removal, a longer cell cycle time of 3-18 days was obtained.

If we had taken the concept of cell loss factor into consideration, we may have obtained smaller values of cell cycle time in every case. Though these calculated data have many uncertain factors as mentioned above, the cell cycle time of glio-blastoma measured in this way corresponds fairly well to the cell cycle time of 2-3 days in glio-blastoma obtained by Hoshino and Wilson.


Copyright © 1975, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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